MR systems HyperEngineered

HyperE designs and produces a novel parahydrogen induced polarization (PHIP) instrument to pave the way for breakthrough of PHIP, an emerging magnetic resonance imaging technique (MRI) with major clinical impact for improvement of diagnostic and therapeutic evaluation of cancer. In conjunction with MRI, PHIP amplifies the inherently low magnetic signal enabling molecular imaging in the human body which to date, is impossible with MRI. PHIP enhances MRI through hyperpolarized injectable agents that report about cellular composition and metabolism, critical factors for identification and tracking of cancer tissue. Commercial PHIP equipment to be coupled with MRI is not available at present. So far, exploration of this promising yet complex technology has been limited to a handful hyperpolarization/MRI research experts with the technical skill and facility to construct their own equipment. Multiple published experimentation results prove that our custom-built polarizer prototype has set the benchmark in performance. After implementation of our design enhancement and upgrades plan, HyperE's research polarizer is expected to be superior in functionality, flexibility, affordability, and usability to any other comparable hyperpolarization instrumentation ever documented. Our ultimate goal is to evolve our unique design to deliver a commercially fabricated product for under US $500k for clinical utilization. We envision that our instrument design will not only represent a significant technological research innovation but open up completely new clinical imaging possibilities not available with current medical practice tools. Moreover, this polarizer is expected to propel MRI combined with PHIP to play a major role in cancer detection and treatment control, joining the ranks of PET and CT.

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PHIP Polarizer

supported by NIH NCI R43 CA224847-01



Best performing | Most reliable | Top user-friendly | Very affordable 13C and 15N Parahydrogen Induced Polarization
1.4 mT magnetic field strength
5 bar parahydrogen pressure from gas storage tank
2-4 mL solution volumes
Temperature control for ambient room temperature to 90o Celsius
Can be used with homogeneous and heterogeneous catalysts
Customizable for individualized polarization transfer sequences
200-watt 2 channel RF amplifier
Quadrature RF input coil
1-minute polarization times

Custom Dual Resonance MR coils

example: Custom built 1H/19F dual tuned coil
Birdcage coil
Orthogonal 1H/19F so both can be tuned simulatenously